Translocon Remodeling Modulates Ribosomal Frameshifting and the Maturation of the Sindbis Virus Structural Polyprotein
Antonio Bonifasi, Gayani Apsara Ranasinghe, Ashish R. Jhangiani, Venkatesh P. Thirumalaikumar, Brianna Corman, Joseph Paul Robinson, Suchetana Mukhopadhyay, Jonathan P. Schlebach
The paper shows that translocon remodeling affects ribosomal frameshifting and viral polyprotein maturation in alphaviruses, reducing viral fitness.
bioRxiv · Aug 4, 2026 · PreprintMolecular Biology