Author

Wesley D. Penn

Indiana University BloomingtonORCID 0000-0001-8930-4091Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Charles P. KuntziD· 2 shared Jonathan P. SchlebachiD· 2 shared Aashish ManglikiD· 1 shared Ali Farzam· 1 shared Antonio Bonifasi· 1 shared Austin Tedman· 1 shared Braden Lewis· 1 shared Brianna N. Corman· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Charles P. KuntzORCID

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2 papers

Recent·Most cited

Feedback from the Nascent Chain Triggers Ribosomal Frameshifting and Transcript Decay

Patrick J. Carmody, Caden R Sillman, Dyotima Dyotima, Rohan Bhardwaj, Ali Farzam, Morvarid Golrokhmofrad, Braden Lewis, Wesley D. Penn, Bryon Drown, Charles P. Kuntz, Jonathan P. Schlebach

The paper shows that nascent polypeptide feedback triggers ribosomal frameshifting and transcript decay through specific motifs and splicing events.

bioRxiv · Dec 26, 2025 · PreprintBiochemistry

Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis

Austin Tedman, Muskan Goel, Sohan Shah, Mathew K. Howard, Laura M. Chamness, Antonio Bonifasi, Ismalia Adams, Jacklyn M. Gallagher, Wesley D. Penn, Katarina Nemec, Eli Fritz McDonald, Brianna N. Corman, Joseph Paul Robinson, Carol Beth Post, Patricia L. Clark, , Jonathan P. Schlebach

The paper introduces a platform to characterize GPCR expression and uses machine learning to identify structural features affecting their biosynthesis.

bioRxiv · Sep 19, 2025 · PreprintBiochemistry