Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer
Niki Tavakoli, Emma J. Fong, Abigail Coleman, Yukai Huang, Mathias Bigger, Michael E. Doche, Seungil Kim, Heinz‐Josef Lenz, Nicholas Alexander Graham, Paul Macklin, Stacey D. Finley, Shannon M. Mumenthaler
The paper integrates computational metabolic modeling with experimental validation to identify hexokinase as a therapeutic target in colorectal cancer by analyzing CAF-conditioned tumor organoids.
npj Systems Biology and Applications · Jan 28, 2025Peer-reviewedSystems Biology