Heinz‐Josef Lenz

The paper integrates computational metabolic modeling with experimental validation to identify hexokinase as a therapeutic target in colorectal cancer by analyzing CAF-conditioned tumor organoids.

This study identifies distinct molecular features of early-onset colorectal cancer in Hispanic/Latino patients through multi-omics analysis, revealing significant WNT pathway alterations and potential therapeutic targets.

This study profiles colorectal cancer in Hispanic/Latino patients, finding high genetic similarity to Peruvians-from-Lima-like populations and identifying key mutations and pathways associated with young-onset disease.

This paper identifies a cis-regulatory mechanism in triple-negative breast cancer where targeting circadian transcription factors with small molecules represses a circadian transcriptional program, offering a new therapeutic strategy.

This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.