Circulating biomarkers reflecting type III, IV and VI collagen remodeling are present in lung tissue of patients with pulmonary fibrosis and non-fibrotic controls
Helene Wallem Breisnes, Sissel Brix Kronborg-White, Mathias Høj, Filipa Bica Simões, Diana Julie Leeming, M.A. Karsdal, Simon Francis Thomsen, Line Bille Madsen, Søren Helbo, Elisabeth M. Bendstrup, Jannie Marie Bülow Sand
This study shows that collagen remodeling biomarkers, found in circulation, are present in lung tissue of pulmonary fibrosis patients and non-fibrotic controls, with distinct spatial distributions.
Scientific Reports · Aug 18, 2026Peer-reviewedMolecular Biology