M.A. Karsdal

The paper shows that in IPF lungs, COL6 gene expression is higher but protein levels and synthesis around airways and vessels are lower, suggesting disrupted matrix organization and fibroblast persistence.

This study shows that collagen remodeling biomarkers, found in circulation, are present in lung tissue of pulmonary fibrosis patients and non-fibrotic controls, with distinct spatial distributions.

This study identifies novel plasma proteomic biomarkers for Dupuytren Disease, showing impaired Collagen I degradation and developing diagnostic risk scores with moderate accuracy.

This study shows that the TNKS inhibitor OM-153 reduces fibrosis markers and ECM expression in multiple preclinical IPF models by inhibiting WNT/β-catenin and YAP signaling.

This study shows that fecal microbial load, not disease, is the main driver of gut microbiome changes and identifies it as a major confounder in microbiome studies.