Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease
Jian-Ping Yang, Rachel Toughiri, Anshu P. Gounder, Dan Scheibe, Matt J. Petrus, Sarah J. Fink, Sébastien Vallée, Jon A. Kenniston, Nikolaos Papaioannou, Steven Langston, Narender R. Gavva, Shane R. Horman
This study identifies small molecule agonists of fetal hemoglobin expression using a reporter cell line, finding novel inducers and confirming mechanisms of action for known compounds.
PLoS ONE · Nov 6, 2024Peer-reviewedCell Biology