Author

Shane R. Horman

Takeda (United States)ORCID 0000-0002-4291-2126Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:batch correction / integration· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Adriana BorowaiD· 1 shared Amanda Lembke· 1 shared Amandine Thibaudeau· 1 shared Amélie Weiss· 1 shared Amy B. GoodaleiD· 1 shared Amy Unruh· 1 shared Anne Elizabeth CarpenteriD· 1 shared Anne-Laure Ong· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBioinformatics

Adriana BorowaORCID

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Author profile →

2 papers

Recent·Most cited

Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease

Jian-Ping Yang, Rachel Toughiri, Anshu P. Gounder, Dan Scheibe, Matt J. Petrus, Sarah J. Fink, Sébastien Vallée, Jon A. Kenniston, Nikolaos Papaioannou, Steven Langston, Narender R. Gavva, Shane R. Horman

This study identifies small molecule agonists of fetal hemoglobin expression using a reporter cell line, finding novel inducers and confirming mechanisms of action for known compounds.

PLoS ONE · Nov 6, 2024Peer-reviewedCell Biology

JUMP Cell Painting chemical dataset: Morphological map of 115,796 compounds in human cells

Srinivas Niranj Chandrasekaran, Jeanelle Ackerman, Eric Alix, Dale Michael Ando, John Arévalo, Melissa Bennion, Nicolas Boisseau, Adriana Borowa, Justin D. Boyd, Laurent Brino, Patrick J. Byrne, Hugo Ceulemans, Carolyn Ch’ng, Beth A. Cimini, Djork-Arné Clevert, , Anne Elizabeth Carpenter

Cell Painting images and profiles for 115,796 compounds in U2OS cells from 12 laboratories; 15.2% of analyzed compounds are phenotypically active, and cross-laboratory replicates cut reference-compound activity by 34%.

bioRxiv · Mar 23, 2023 · PreprintBioinformatics✦ In-depth digest