Machine learning-assisted directed evolution yields dramatic improvement on novel AAV engineering task
Marina Luchner, Ioulia Vorobieva, Ruhani Makkar, Mattea Jozinovic, Simon Chester, Matthew J A Wood, Stephan Sanders, Dhanu Gupta, Harrison Steel
This study shows ML-assisted directed evolution improves AAV capsid manufacturing efficiency 41-fold compared to directed evolution alone.
bioRxiv · Oct 7, 2026 · PreprintBioengineering