A detailed kinetic model of Eastern equine encephalitis virus replication in a susceptible host cell
Caroline I. Larkin, Matthew D. Dunn, Jason E. Shoemaker, William B. Klimstra, James R. Faeder
This paper develops a rule-based kinetic model of EEEV replication in mammalian cells, calibrated with experimental data, revealing ribosome density on viral RNA as critical for rapid replication and identifying transcription as a therapeutic target.
PLoS Computational Biology · Jun 4, 2025Peer-reviewedSystems Biology