William B. Klimstra

This study identifies three HS-binding sites on EEEV E2 glycoprotein that contribute to both HS and protein receptor-dependent infection, affecting disease and mosquito infectivity.

This paper develops a rule-based kinetic model of EEEV replication in mammalian cells, calibrated with experimental data, revealing ribosome density on viral RNA as critical for rapid replication and identifying transcription as a therapeutic target.