Author

Caroline I. Larkin

University of PittsburghORCID 0000-0002-0206-277XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Approach:simulation· 1 Research Focus:software / tool· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

James R. FaederiD· 2 shared Jason E. ShoemakeriD· 2 shared Aarthi NarayananiD· 1 shared Adrianne L. JenneriD· 1 shared Ali Sinan SaglamiD· 1 shared Amber M. SmithiD· 1 shared Andrew BeckeriD· 1 shared Ashlee N. Ford VersyptiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

James R. FaederORCID

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2 papers

Recent·Most cited

Systems BiologyPLoS Computational BiologyPeer-reviewedJun 4, 2025

A detailed kinetic model of Eastern equine encephalitis virus replication in a susceptible host cell

Caroline I. Larkin, Matthew D. Dunn, Jason E. Shoemaker…·James R. Faeder

This paper develops a rule-based kinetic model of EEEV replication in mammalian cells, calibrated with experimental data, revealing ribosome density on viral RNA as critical for rapid replication and identifying transcription as a therapeutic target.

2 citations

humanstatistical model

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Systems BiologybioRxivPreprintApr 2, 2020

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Iterative community-driven development of a SARS-CoV-2 tissue simulator

Michael Getz, Yafei Wang, Gary C. An…·Paul Macklin

Open-source agent-based PhysiCell model of SARS-CoV-2 infection in lung epithelium; version 5 clears virus in about 6 days in simulation, and delayed T cell arrival increases epithelial loss.

61 citations

virushuman

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