The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction
Edward Alain B. Pajarillo, Sang Hoon Kim, Alexis Digman, Matthew Dutton, Deok‐Soo Son, Michael Aschner, Eun-Sook Lee
This study investigates how manganese exposure increases microglial LRRK2 activity, leading to neuroinflammation and toxicity, with exacerbation in LRRK2 G2019S mutation.
bioRxiv · Apr 3, 2023 · PreprintNeuroscience