The Immune-Mutation Axis of Cancer Incidence: Insights from 30,000 TCRβ Repertoires
Harus Jabran Zahid, Matthew E. Lee, Ruth T. Taniguchi, Gheath Alatrash, Thomas McFall, Marco Garcia Noceda, Harlan S. Robins, Julia Greissl
The paper analyzes TCRβ repertoires from 30,000 individuals to show that immune decline with age correlates with cancer incidence, revealing an immune-mutation balance in carcinogenesis.
bioRxiv · Oct 21, 2024 · PreprintCancer Biology