Harus Jabran Zahid

The paper identifies a separable organization of immune transcriptional responses across cell types using single-cell data from peripheral blood mononuclear cells exposed to cytokines.

The paper shows that immune organization is reflected in coordinated transcriptional changes across cell types, forming a shared low-dimensional state space that persists across tissues and time.

This study identifies HLA allele-specific biases in TCR Vβ usage, showing germline-encoded preferences shape TCR-HLA compatibility and influence TCR-pHLA specificity.

The paper analyzes TCRβ repertoires from 30,000 individuals to show that TCR diversity is primarily determined by repertoire size and the frequency of the 1,000 most abundant clones, explaining 96% of variance in diversity.

The paper maps T-cell receptor β sequences to specific HLA allotypes using population-level TCR repertoire data, enabling accurate HLA imputation and revealing insights into TCR-HLA interactions.

The paper identifies public TCRB sequences expanded in CD or UC, associated with HLA alleles and antigen-specific immune responses, showing differential expansion in CD compared to UC and healthy controls.

The paper analyzes TCRβ repertoires from 30,000 individuals to show that immune decline with age correlates with cancer incidence, revealing an immune-mutation balance in carcinogenesis.