Matthew P. Brember

Toxoplasma strikes preemptively to swiftly suppress macrophage immune response during active infection

This study uses time-resolved transcriptomic profiling to analyze host and parasite gene expression during early Toxoplasma gondii infection in mouse macrophages, revealing rapid host immune responses and delayed parasite transcriptional activation.

Activity of Salmonella SPI-1 inhibits the TLR4-dependent transcriptional but not translational response during macrophage infection

Salmonella injectisome penetration of macrophages triggers rapid translation of transcription factors and protection against cell death

The paper shows that Salmonella uses the SPI-1 injectisome to trigger rapid translation of transcription factors in macrophages, which suppresses inflammation and cell death to aid infection.