George Wood

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

This study uses time-resolved transcriptomic profiling to analyze host and parasite gene expression during early Toxoplasma gondii infection in mouse macrophages, revealing rapid host immune responses and delayed parasite transcriptional activation.

The paper shows that Salmonella uses the SPI-1 injectisome to trigger rapid translation of transcription factors in macrophages, which suppresses inflammation and cell death to aid infection.