Impaired motor activity in a CRISPR SCA5 L253P knock-in mouse is associated with selective beta-III-spectrin subcellular redistribution in the cerebellum
Adam W. Avery, Brennon L. O’Callaghan, Matthew T. Thiel, Sarah A. Denha, Devon G O'Callaghan, Emma Cismas, Jared A. Lamp, Harry T. Orr, Thomas S. Hays
This paper develops a CRISPR knock-in mouse model of SCA5 L253P mutation, showing impaired motor activity and altered beta-III-spectrin localization in cerebellar Purkinje neurons.
bioRxiv · Mar 17, 2026 · PreprintNeuroscience