H2AX C-Terminal Dipeptide Truncation: A Master Switch of the DNA Damage Response.
Faith M Joseph, Matthew V. Holt, John Michael Jerome, Linda Zhang, Ashley Boice, Patricia D. Castro, Sofía I. Aramburu, Ruhee Dere, Susan M. Rosenberg, David R. Rowley, Nicolas L. Young
This paper identifies KDM4A-mediated H2AX truncation as a mechanism that suppresses DNA damage response signaling by preventing γH2AX formation.
bioRxiv · May 11, 2026 · PreprintMolecular Biology