Author

Nicolas L. Young

Baylor College of MedicineORCID 0000-0002-3323-2815Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Karl F. PonchaiD· 2 shared Alli M. Nuotio-AntariD· 1 shared Alyssa T. PaparellaiD· 1 shared Ashley BoiceiD· 1 shared B Rutledge Smith· 1 shared Bethany C. TayloriD· 1 shared Bria GrahamiD· 1 shared Brian D. StrahliD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

Karl F. PonchaORCID

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Author profile →

4 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 11, 2026

H2AX C-Terminal Dipeptide Truncation: A Master Switch of the DNA Damage Response.

Faith M Joseph, Matthew V. Holt, John Michael Jerome…·Nicolas L. Young

This paper identifies KDM4A-mediated H2AX truncation as a mechanism that suppresses DNA damage response signaling by preventing γH2AX formation.

DOI 10.64898/2026.05.07.723272

experimental assay

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BiochemistryJournal of Proteome ResearchPeer-reviewedFeb 28, 2025

Normalized and Directional Interplay Scoring for the Interrogation of Proteoform Data

Karl F. Poncha, Alyssa T. Paparella, Nicolas L. Young

The paper introduces two new PTM crosstalk scores to analyze histone proteoform dynamics in mouse organs during aging and demonstrates their application using proteoform data.

2 citations

mouseproteomics

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BiochemistryJournal of Biological ChemistryPeer-reviewedJul 1, 2024

H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation

Geoffrey Fox, Karl F. Poncha, B Rutledge Smith…·Kanishk Jain

The paper shows that H3K18 and H3K23 acetylation enhance MLL1-mediated H3K4 methylation, while other modifications are less affected by tail acetylation.

23 citations

ChIP-seqproteomics

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Systems BiologyEpigenetics & ChromatinPeer-reviewedApr 27, 2024

Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress

Bethany C. Taylor, Loic H. Steinthal, Michelle Dias…·Alli M. Nuotio-Antar

The paper quantifies histone modifications and DNA methylation in mouse BAT under different cold conditions, revealing epigenetic changes linked to thermogenic response.

12 citations

mouseDNA methylation

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