Author

Matthew Weinstock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:E. coli· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Abigail B. VenturaiD· 2 shared Anand V. SastryiD· 2 shared Christa Kohnert· 2 shared Gregory HannumiD· 2 shared Hayley Carter· 2 shared Jahir M. GutierreziD· 2 shared Jennifer T. Stanton· 2 shared John M. SuttoniD· 2 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Abigail B. VenturaORCID

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Author profile →

2 papers

Recent·Most cited

Deep learning-based codon optimization with large-scale synonymous variant datasets enables generalized tunable protein expression

David A. Constant, Jahir M. Gutierrez, Anand V. Sastry, Rebecca Viazzo, Nicholas R. Smith, Jubair Hossain, David A. Spencer, Hayley Carter, Abigail B. Ventura, Michael T. M. Louie, Christa Kohnert, Rebecca Consbruck, Joshua Bennett, Kenneth A. Crawford, John M. Sutton, , Miles W. Gander

The paper develops deep learning models trained on synonymous variant datasets to predict and optimize protein expression in E. coli.

bioRxiv · Feb 11, 2023 · PreprintSynthetic Biology

Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness

Sharrol T. Bachas, Goran Rakocevic, David Spencer, Anand V. Sastry, Robel Gemechu Haile, John M. Sutton, George W. Kasun, Andrew L. Stachyra, Jahir M. Gutierrez, Edriss Yassine, Borka Medjo, Vincent Blay, Christa Kohnert, Jennifer T. Stanton, Alexander Brown, , Roberto Spreafico

Language models trained on high-throughput affinity data predict KD of unseen antibody variants across three orders of magnitude, and a "naturalness" score can be optimised alongside affinity.

bioRxiv · Aug 16, 2022 · PreprintBioinformatics