Cross-presentation of citrullinated antigens drives cytotoxic CD8+ T cell responses in rheumatoid arthritis
Jae‐Seung Moon, Mengrui Zhang, Laura S. van Dam, Eun Kyung Song, Orr Sharpe, Julie Carman, Daniel Candala Ramírez, Melanie H. Smith, Laura T. Donlin, Maureen Howard, Mark M. Davis, William H. Robinson
The paper identifies a mechanism where TLR4-driven cross-presentation of citrullinated antigens by dendritic cells and autoreactive B cells activates CD8+ T cells in rheumatoid arthritis.
bioRxiv · Jun 8, 2026 · PreprintImmunology