Mengrui Zhang

CD19-CAR T-cell therapy resets the EBV+ autoreactive B cell repertoire in autoimmune disease

This study shows CD19-CAR T-cell therapy depletes EBV+ autoreactive B cells and resets their repertoire, leading to sustained remission, while rituximab does not.

Aneuploidy profiling among different types of brain metastases reveals a colon cancer-specific chromosomal signature

This study identifies a unique aneuploidy profile in colorectal cancer brain metastases compared to other cancer types and metastatic sites.

Cross-presentation of citrullinated antigens drives cytotoxic CD8+ T cell responses in rheumatoid arthritis

The paper identifies a mechanism where TLR4-driven cross-presentation of citrullinated antigens by dendritic cells and autoreactive B cells activates CD8+ T cells in rheumatoid arthritis.

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis

The paper identifies four synovial transcriptional clusters in knee OA linked to cartilage degeneration severity through bulk and single-cell RNA-seq analyses.

Colorectal cancer relies on an immunosuppressive cellular topography and genomic adaptations for establishing brain metastases

This study identifies the immunosuppressive cellular and genomic features of colorectal cancer brain metastases and their mechanisms of adaptation.

Senescent Activated Naive B Cells Promote Anti-Citrullinated Antigen T Cell Responses and the Transition to Clinical Rheumatoid Arthritis

This study identifies senescent activated naive B cells in ACPA+ individuals that promote anti-citrullinated antigen T cell responses and drive progression to clinical RA.

DeepCEF: A Deep Causal Estimation Framework for Complex Biological Systems Integrating Local Scores, Independence Tests, and Relation Attributes

This paper introduces a deep learning framework for causal estimation in complex biological systems, combining local scores, independence tests, and variable attributes to improve accuracy and adaptability.

The Microbiome and Metatranscriptome of a Panel from the Sarracenia Mapping Population Reveal Complex Assembly and Function Involving Host Influence.

This study analyzes the microbiome and metatranscriptome of Sarracenia species to reveal host-influenced community structure and functional convergence.

Genome report: Whole genome sequence and annotation of Penstemon davidsonii

This paper reports the first reference genome assembly and annotation for Penstemon davidsonii using PacBio long-read sequencing and Hi-C scaffolding.

Drug Screening with Zebrafish Visual Behavior Identifies Carvedilol as a Potential Treatment for Retinitis Pigmentosa

This study screens drugs using zebrafish visual behavior to identify carvedilol as a potential treatment for retinitis pigmentosa.