Illuminating protein space with a programmable generative model
John Ingraham, Max Baranov, Zak Costello, Karl W. Barber, Wujie Wang, Ahmed Ismail, Vincent Frappier, Dana M. Lord, Christopher Ng‐Thow‐Hing, Erik R. Van Vlack, Shan Tie, Vincent Xue, Sarah C. Cowles, Alan Leung, João V. Rodrigues, , Gevorg Grigoryan
This paper introduces Chroma, a generative model for proteins that can sample novel structures and sequences, conditioned on desired properties and functions.
Nature · Nov 15, 2023Peer-reviewedBioinformatics