Author

Vincent Frappier

Massachusetts Institute of TechnologyORCID 0000-0002-4281-3128Unclaimed ORCID profile · follow to get notified of new preprints

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Vincent Frappier1 paper

Biology Disciplines

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Bioinformatics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein structure· 2 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam R. RootiD· 2 shared Alan LeungiD· 2 shared Claudio L. Morales-Pérez· 2 shared Dana M. LordiD· 2 shared Gevorg GrigoryaniD· 2 shared Zak Costello· 2 shared Ahmed IsmailiD· 1 shared Alex AyoubiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMicrobiology

Adam R. RootORCID

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3 papers

Recent·Most cited

Functional and structural characterization of a combination of pan-sarbecovirus antibodies with potent antiviral activity

Grace Marden, Kimberly P. Schmitt, Maxwell I. Zimmerman, Alex H. Ramos, Monica Menzenski, Geetika Sharma, Hongru Li, Eric Carlin, Anne M. Jecrois, Claudio L. Morales-Pérez, Eugene J. Palovcak, Joseph D. Garlick, Brett T. Hannigan, Pamela Joan Russell, Ross S. Federman, , Francesco Borriello

This study identifies two broadly neutralizing sarbecovirus antibodies that resist viral evolution and show improved neutralization when combined.

bioRxiv · Mar 30, 2025 · PreprintMicrobiology

Illuminating protein space with a programmable generative model

John Ingraham, Max Baranov, Zak Costello, Karl W. Barber, Wujie Wang, Ahmed Ismail, Vincent Frappier, Dana M. Lord, Christopher Ng‐Thow‐Hing, Erik R. Van Vlack, Shan Tie, Vincent Xue, Sarah C. Cowles, Alan Leung, João V. Rodrigues, , Gevorg Grigoryan

This paper introduces Chroma, a generative model for proteins that can sample novel structures and sequences, conditioned on desired properties and functions.

Nature · Nov 15, 2023Peer-reviewedBioinformatics

The Elastic Network Contact Model applied to RNA: enhanced accuracy for conformational space prediction

Olivier Mailhot, Vincent Frappier, François Major, Rafaël Najmanovich

The paper adapts the Elastic Network Contact Model (ENCoM) for RNA dynamics, showing improved accuracy in predicting conformational changes and structural variance compared to existing methods.

bioRxiv · Oct 4, 2017 · PreprintBioinformatics