João V. Rodrigues

Chaperonin recognition of protein dynamics drives drug resistance

The paper shows that chaperonin GroEL/S promotes drug resistance by recognizing protein dynamics, displacing inhibitors and restoring active enzyme function.

Illuminating protein space with a programmable generative model

This paper introduces Chroma, a generative model for proteins that can sample novel structures and sequences, conditioned on desired properties and functions.

Empowering systems-guided drug target discovery with metabolic and structural analysis

This study combines machine learning with metabolic and structural analysis to identify specific drug targets from metabolomics data, using a case study of a DHFR-targeting antibiotic.

Proteostasis environment shapes higher-order epistasis operating on antibiotic resistance

The paper investigates how proteostasis machinery influences higher-order epistasis in antibiotic resistance traits across different bacterial species.