Author

Max C. Mendrzycki

University of Virginia

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Biology Disciplines

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Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander D. SorkiniD· 1 shared Kevin BrowniD· 1 shared Leslie M. LoewiD· 1 shared Matthew J. LazzaraiD· 1 shared Paul J. MyersiD· 1 shared Sung Hyun LeeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperSystems Biology

Alexander D. SorkinORCID

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1 paper

Recent·Most cited

Systems-level Consequences of Low RAF Abundance for EGFR-ERK Signaling

Sung Hyun Lee, Paul J. Myers, Max C. Mendrzycki, Kevin Brown, Leslie M. Loew, Alexander D. Sorkin, Matthew J. Lazzara

The paper develops computational models of the EGFR-ERK pathway to show that low RAF abundance creates signaling bottlenecks and stochastic dynamics, affecting ERK activation and RAS-RAF interactions in cancer cells.

Biophysical Journal · Jan 6, 2026Peer-reviewedSystems Biology