Alexander D. Sorkin

Traffickome infers directed, compartment-resolved membrane trafficking from proteomic data

Traffickome infers directed membrane trafficking between cellular compartments from proteomic data, achieving high accuracy in predicting trafficking transitions.

Small-molecule CBLB inhibitor abolishes EGFR ubiquitination, reduces receptor endocytosis and diminishes cell motility signaling

The paper uses a CBLB inhibitor to show that EGFR ubiquitination is essential for clathrin-mediated endocytosis and cell motility, but not for other downstream signaling pathways.

Systems-level Consequences of Low RAF Abundance for EGFR-ERK Signaling

The paper develops computational models of the EGFR-ERK pathway to show that low RAF abundance creates signaling bottlenecks and stochastic dynamics, affecting ERK activation and RAS-RAF interactions in cancer cells.

The Chromosome 19 miRNA Cluster Guards Trophoblasts Against Overacting Innate Immunity

The paper investigates the role of C19MC microRNAs in trophoblasts, showing they suppress innate immune activation by interfering with TLR3.

Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters during collective cell migration of epithelial cells

This study shows low-affinity EGFRLs like EREG and AREG transmit signals more efficiently than high-affinity ligands during collective cell migration and wound healing.

E3 ligase recruitment by UBQLN2 protects substrates from proteasomal degradation

This study shows UBQLN2 stabilizes substrates by recruiting E3 ligases, which promotes phase separation and protects against proteasomal degradation, and this mechanism is disrupted in ALS mutants.

Endocytic down-regulation of the striatal dopamine transporter by amphetamine in sensitized mice in sex-dependent manner

This study shows that amphetamine induces sex-dependent endocytic down-regulation of the dopamine transporter in sensitized mice, with effects observed in the nucleus accumbens but not the dorsal striatum.

Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR

The paper uses proximity labeling and mass spectrometry to identify proteins associated with internalized EGFR, revealing TFG's role in endosomal sorting.

A spatially resolved EGFR signaling model predicts the length scale of GAB1-SHP2 complex persistence

The paper develops a reaction-diffusion model to predict the spatial persistence of GAB1-SHP2 complexes downstream of EGFR activation and validates it with experiments.