Sung Hyun Lee

The paper models PTPRJ's role in regulating cell phenotypes through RTK signaling pathways in cancer cells, identifying context-dependent mechanisms.

The paper develops computational models of the EGFR-ERK pathway to show that low RAF abundance creates signaling bottlenecks and stochastic dynamics, affecting ERK activation and RAS-RAF interactions in cancer cells.

The paper develops a computational model to predict cell responses to EGFR ligands by integrating mechanistic and data-driven approaches, revealing how ligand affinity and signaling pathways influence phenotypes.