Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6
Anna A. Cook, Tsz Chui Sophia Leung, Max Rice, Maya Nachman, Élyse Zadigue-Dubé, Alanna Jean Watt
This study identifies endosomal dysfunction in SCA6 mouse models, linking it to impaired BDNF-TrkB signaling and proposing endo-lysosomal targeting as a therapeutic strategy.
eLife · Aug 18, 2023Peer-reviewedNeuroscience