Alanna Jean Watt

This study shows that zebrin molecular identity and cerebellar location determine Purkinje cell vulnerability in Christianson syndrome mice, with anterior zebrin-negative cells dying earlier than posterior cells.

The paper compares cerebellar astrocytes and Purkinje cells across humans, macaques, and mice, finding species-specific differences in distribution, size, and marker expression.

The paper maps Purkinje cell connectivity to cerebellar nuclear neurons, finding non-random, zone-specific patterns and suggesting that small Purkinje inputs can pause nuclear neuron output.

This study identifies endosomal dysfunction in SCA6 mouse models, linking it to impaired BDNF-TrkB signaling and proposing endo-lysosomal targeting as a therapeutic strategy.

This study shows that restoring BDNF-TrkB signaling through exercise or a BDNF mimetic improves motor coordination and cerebellar function in a mouse model of SCA6.

The paper shows that local axonal translation regulates synapse-type-specific neurotransmission in the primary visual cortex through mTOR and cap-dependent mechanisms.