Author

Tsz Chui Sophia Leung

McGill UniversityORCID 0000-0003-2158-4300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Alanna Jean WattiD· 2 shared Anna A. CookiD· 2 shared Eileen McNicholasiD· 1 shared Élyse Zadigue-Dubé· 1 shared Eviatar FieldsiD· 1 shared Jacky Sheng· 1 shared Lois LauiD· 1 shared Max Rice· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Alanna Jean WattORCID

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2 papers

Recent·Most cited

NeuroscienceeLifePeer-reviewedAug 18, 2023

Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6

Anna A. Cook, Tsz Chui Sophia Leung, Max Rice…·Alanna Jean Watt

This study identifies endosomal dysfunction in SCA6 mouse models, linking it to impaired BDNF-TrkB signaling and proposing endo-lysosomal targeting as a therapeutic strategy.

7 citations

mousebulk RNA-seq

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NeuroscienceScience AdvancesPeer-reviewedSep 16, 2022

Restoration of BDNF-TrkB signaling rescues deficits in a mouse model of SCA6

Anna A. Cook, Sriram Jayabal, Jacky Sheng…·Alanna Jean Watt

This study shows that restoring BDNF-TrkB signaling through exercise or a BDNF mimetic improves motor coordination and cerebellar function in a mouse model of SCA6.

32 citations

mouseexperimental assay

𝕏 PostBluesky