Seeded propagation of alpha-synuclein aggregation in mouse brain using protein misfolding cyclic amplification
Simon Nicot, Jérémy Verchère, Maxime Bélondrade, Charly Mayran, Dominique Bétemps, Daisy Bougard, Thierry Baron
This study uses PMCA to show that alpha-synuclein aggregates from mutant mice can seed aggregation in wild-type mice and other substrates, mimicking prion-like behavior.
bioRxiv · Jan 26, 2019 · PreprintNeuroscience