Pathogenic Viruses, Genome Integrations, and Viral::Human Chimeric Transcripts Detected by VirusIntegrationFinder Across >30k Human Tumor and Normal Samples
Brian J. Haas, Anne Van Arsdale, Alexander Dobin, Maxwell W. Brown, Joshua Gould, Christophe Georgescu, Eleanor J Agosta, Sylvain Baulande, Ismail Jamail, Maud T Kamal, Ivan Bièche, Jack Lenz, Cristina Montagna, Aziz M. Al’Khafaji
The paper develops a tool to detect viral integrations in human genomes and applies it to over 30,000 tumor samples, identifying virus-human chimeric transcripts and insertion hotspots.
bioRxiv · Mar 10, 2025 · PreprintCancer Biology