A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling
Samuel F. Chang, Chae‐Myeong Ha, Manoja Kumar Brahma, Luke Potter, Mahima S. Reddy, Sayan Bakshi, Kerstin Preuß, Md Saimoon Rahman, Johannes K. Fischer, Caitlin A. Harrell, Zhihuan Sun, John C. Chatham, Adam R. Wende
This study shows that transiently increased cardiomyocyte O-GlcNAcylation worsens cardiac remodeling after pressure overload, supporting the concept of O-GlcNAc memory as part of metabolic memory.
Journal of the American Heart Association · Aug 31, 2026Peer-reviewedMolecular Biology