Adam R. Wende

A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling

This study shows that transiently increased cardiomyocyte O-GlcNAcylation worsens cardiac remodeling after pressure overload, supporting the concept of O-GlcNAc memory as part of metabolic memory.

ER Stress-Induced beta-Cell Apoptosis is Linked to Novel Select Lipid Signaling at the Transcriptional Level: Implications in T1D Development

This study identifies a novel lipid signaling pathway involving iPLA2β that links ER stress to β-cell apoptosis in T1D, revealing transcriptional regulation by iDLs and potential therapeutic targets.

FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes

This study shows that FGF21-FGFR4 signaling in cardiac myocytes causes concentric hypertrophy in diabetic mice, suggesting it may contribute to HFpEF and that FGFR4 blockade could be a therapeutic target.

Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets

This study identifies transcriptional regulators and networks mediating islet adaptation during pregnancy through transcriptomic analysis of beta-cells in mice.