Neutrophil Transcriptomics in SLE: Exploring Intrinsic, Ex Vivo Adaptation, and CAR T-Cell Therapy-Induced Changes
Ehsan Dehdashtian, Guangnan Hu, Leah M. Whiteman, Md Tanimul Islam, Stefania Gallucci, Manuel G. Garber, Dominic C. Borie, Georg Andreas Schett, Roberto Caricchio
This study identifies transcriptomic differences in SLE neutrophils, shows shared ex vivo adaptation with healthy cells, and demonstrates CAR T-cell therapy can reset neutrophil gene expression toward healthy patterns.
bioRxiv · Nov 3, 2025 · PreprintImmunology