Manuel G. Garber

This study identifies MMP9+ CD14+ myeloid cells as key drivers of UVB-induced IFN-I-driven inflammation in cutaneous lupus and dermatomyositis through a keratinocyte-fibroblast-myeloid circuit.

This study shows that endothelial cells with a STINGV154M mutation cause persistent skin inflammation after UVB exposure, linking STING activation to impaired myeloid cell recruitment and delayed inflammation resolution.

This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.

The paper introduces a scalable TCR synthesis and screening method, TCRAFT, to map antigen reactivity in vitiligo and pancreatic ductal adenocarcinoma.

This study identifies transcriptomic differences in SLE neutrophils, shows shared ex vivo adaptation with healthy cells, and demonstrates CAR T-cell therapy can reset neutrophil gene expression toward healthy patterns.

This study investigates HCMV infection in primary human oral keratinocytes, showing it drives dysregulated intermediate differentiation and alters immune responses to support viral replication.

The paper introduces Worm Perturb-Seq (WPS) to perform high-resolution RNA-seq on perturbed C. elegans, identifying gene regulatory networks and showing pairwise modularity in nuclear hormone receptor regulation.

This study creates a single-cell RNA-seq atlas of the mouse seminal vesicle, identifying secretory and immune cell populations and their transcriptomes.

This study uses single-cell RNA sequencing to analyze a FXS mouse model, revealing cell-type specific dysregulation and potential mTOR pathway differences.

The paper introduces multi-CUT&Tag, a method to simultaneously map multiple chromatin proteins in single cells, revealing co-localization and cell-type-specific chromatin features.

The paper creates a single-cell atlas of the murine epididymis and vas deferens, identifying cell types and their regional specialization, and revealing potential signaling networks.

DolphinNext provides a graphical interface for creating, deploying, and executing Nextflow pipelines to improve reproducibility and portability in genomic data analysis.

The paper uses single-cell RNA sequencing to study influenza infection in human nasal washes, identifying a novel goblet cell population and tracking viral variation across infected individuals.

The paper identifies four human adipocyte subtypes through single-cell transcriptomics and describes their developmental mechanisms and functional roles.

DEBrowser provides an interactive tool for differential expression analysis of count data without programming skills, demonstrating its capabilities on published datasets.

The paper introduces SPRITE, a method for detecting higher-order DNA interactions, and shows that nuclear bodies act as inter-chromosomal hubs shaping 3D genome organization.

The paper uses ribosome profiling and RNA-Seq in budding yeast to analyze the translational effects of tRNA modifications, identifying new roles in gene regulation and retroelement control.