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Meera Shah

Sanford Burnham Prebys Medical Discovery Institute

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Approach:statistical model· 1

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Dieter A WolfiD· 1 shared Dietrich FlockerziiD· 1 shared Ronny StraubeiD· 1 shared

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Dieter A WolfORCID

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Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire

Ronny Straube, Meera Shah, Dietrich Flockerzi, Dieter A Wolf

The paper uses mathematical modeling to show that Cand1 exchange activity creates a trade-off between ligase activity and receptor exchange, optimizing substrate degradation and enabling flexible CRL repertoire adjustment.

PLoS Computational Biology · Nov 17, 2017Peer-reviewedSystems Biology