Dieter A Wolf

The paper shows that 5' UTR binding sites for eIF3 on ER membrane protein mRNAs retain eIF3 on 80S ribosomes, promoting co-translational folding and preventing misfolding and sequestration into ER whorls.

The paper uses mathematical modeling to show that Cand1 exchange activity creates a trade-off between ligase activity and receptor exchange, optimizing substrate degradation and enabling flexible CRL repertoire adjustment.