Ronny Straube

Mechanistic modeling suggests stroma-targeting antibody-drug conjugates as an alternative to cancer-targeting in cases of heterogeneous target expression

This paper uses mathematical models to compare cancer-targeting and stroma-targeting ADCs, finding that stroma-targeting may be more effective in cases of heterogeneous antigen expression.

Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire

The paper uses mathematical modeling to show that Cand1 exchange activity creates a trade-off between ligase activity and receptor exchange, optimizing substrate degradation and enabling flexible CRL repertoire adjustment.

Operating regimes of covalent modification cycles at high enzyme concentrations

The paper analyzes the Goldbeter-Koshland model under high enzyme concentrations, identifying conditions for enhanced sensitivity and concentration robustness.