Author

Megan L. O'Mara

Australian Institute of Bioengineering and Nanotechnology;

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ada S. Quinn· 1 shared Alisa GlukhovaiD· 1 shared Andrew P. LeisiD· 1 shared Billy J. Williams-Noonan· 1 shared Gunnar Schulte· 1 shared Hariprasad VenugopaliD· 1 shared Joshua R. Prendergast· 1 shared Kevin HuynhiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ada S. Quinn

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1 paper

Recent·Most cited

Structural basis for inefficient G protein coupling by Frizzled receptors

Wessel A. C. Burger, Susovan Das, Hariprasad Venugopal, Ada S. Quinn, Billy J. Williams-Noonan, Lilian L. L. Wong, Tin T. Nguyen, Joshua R. Prendergast, Nicholas S. Kirk, Andrew P. Leis, Marija Dramicanin, Tracy Josephs, Matthew E. Call, Gunnar Schulte, Megan L. O'Mara, , Alisa Glukhova

The paper identifies detergent LMNG as stabilizing a weak FZD-G protein interface, revealing that FZDs inherently weakly couple to G proteins and preferentially signal through DVL.

bioRxiv · Nov 5, 2026 · PreprintBiochemistry