EZH2 Inhibition Reshapes 3D Chromatin Architecture to Induce Immunogenic Phenotype in Small Cell Lung Cancer
Sana Parveen, Ramesh Adhinaveni, Kun Fang, Lavanya Choppavarapu, Meijun Du, Gustavo W. Leone, Navonil De Sarkar, Victor X. Jin, Hui-Zi Chen
This study shows that inhibiting EZH2 alters 3D chromatin structure in SCLC, reactivating MHC genes and enhancing immunogenicity.
bioRxiv · Jan 28, 2026 · PreprintGenomics