Author

Gustavo W. Leone

Medical College of WisconsinORCID 0000-0002-7617-7449Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Developmental Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Abhik SahaiD· 1 shared Ananya GhoshiD· 1 shared Anindya DuttaiD· 1 shared Anthony J. Trimboli· 1 shared Cynthia Dawn TimmersiD· 1 shared Etsuko Shibata· 1 shared Hui-Zi CheniD· 1 shared Isaac Segura Rueda· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperDevelopmental Biology

Abhik SahaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

EZH2 Inhibition Reshapes 3D Chromatin Architecture to Induce Immunogenic Phenotype in Small Cell Lung Cancer

Sana Parveen, Ramesh Adhinaveni, Kun Fang, Lavanya Choppavarapu, Meijun Du, Gustavo W. Leone, Navonil De Sarkar, Victor X. Jin, Hui-Zi Chen

This study shows that inhibiting EZH2 alters 3D chromatin structure in SCLC, reactivating MHC genes and enhancing immunogenicity.

bioRxiv · Jan 28, 2026 · PreprintGenomics

DNA replication in primary hepatocytes without the six-subunit ORC

Róża K. Przanowska, Yuechuan Chen, Takayuki-Okano Uchida, Etsuko Shibata, Xiaoxiao Hao, Isaac Segura Rueda, Kate N. Jensen, Piotr Przanowski, Anthony J. Trimboli, Yoshiyuki Shibata, Gustavo W. Leone, Anindya Dutta

This study shows that primary hepatocytes can replicate DNA without ORC2, similar to cancer cell lines, by loading MCM2-7 complexes.

eLife · Apr 30, 2025Peer-reviewedGenetics

A Single Trophoblast Layer Acts as the Gatekeeper at the Endothelial-Hematopoietic Crossroad in the Placenta

Pratik Home, Ananya Ghosh, Ram Parikshan Kumar, Soma S. Ray, Sumedha Gunewardena, Rajnish Kumar, Purbasa Dasgupta, Namrata Roy, Abhik Saha, Madhu Micheal Ouseph, Gustavo W. Leone, Soumen Paul

The paper shows that parietal trophoblast giant cells regulate hematopoietic stem cell development in the placenta through paracrine signaling.

bioRxiv · Jul 12, 2024 · PreprintDevelopmental Biology

Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images

Thierry Pécot, Maria C. Cuitiño, Roger H. Johnson, Cynthia Dawn Timmers, Gustavo W. Leone

The paper develops a deep learning approach to estimate cell cycle protein expression from 2D fluorescent images by segmenting nuclei and quantifying fluorescent labels.

PLoS Computational Biology · Mar 14, 2022Peer-reviewedBioinformatics