Differential Effects of Neutral Sphingomyelinase and Serine Palmitoyltransferase Inhibitors on Alzheimer's-Like Neuropathology.
Melina Bellotto, Nicolás González Pérez, Melisa Bentivegna, Martín Carrera, Jessica Presa, Ángeles Vinuesa, Carlos Javier Pomilio, Flavia Saravia, Juan Beauquis
This study compares the effects of nSMase and SPT inhibitors on Alzheimer's-like pathology in mice, finding that nSMase inhibition reduces neuropathology while SPT inhibition worsens it.
bioRxiv · Sep 11, 2026 · PreprintNeuroscience