Author

Melissa H. Cessna

Intermountain Healthcare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Nicola J. CampiD· 3 shared A. Heather EliasseniD· 2 shared Alison M. DunningiD· 2 shared Alpa V. PateliD· 2 shared Anna González‐NeiraiD· 2 shared Anna JakubowskaiD· 2 shared Arto MannermaaiD· 2 shared Christopher A. HaimaniD· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Nicola J. CampORCID

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Author profile →

4 papers

Recent·Most cited

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

Maria Zanti, Denise G O'Mahony, Michael T. Parsons, Leila Dorling, Joe Dennis, Nicholas James Boddicker, Wenan Chen, Chunling Hu, Marc Naven, Kristia Yiangou, Thomas U. Ahearn, Christine B. Ambrosone, Irene Louise Andrulis, Antonis C. Antoniou, Paul Livermore Auer, , Gary Zirpoli

The paper uses case-control data from over 400,000 women to classify BRCA1 and BRCA2 variants, finding high consistency with ClinVar annotations for 785 previously unclassified variants.

Nature Communications · May 24, 2025Peer-reviewedGenetic & Genomic Medicine

Exome Sequencing for Head and Neck Cancer Predisposition Genes

Yao Yu, Bing Feng, Chun-Pin E. Chang, Russell Bell, Austin Wood, Ryan Bohlender, Erich M. Sturgis, Guojun Li, Andrew F. Olshan, Chien‐Jen Chen, Pei‐Jen Lou, Wan-Lun Hsu, Melissa H. Cessna, Benjamin L. Witt, Deborah Wood Neklason, , Sean V. Tavtigian

This study identifies 27 genes associated with head and neck cancer risk through exome sequencing and finds significant interactions between DNA repair gene variants and cigarette smoking.

medRxiv · Jan 20, 2025 · PreprintGenetic & Genomic Medicine

Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction

Kristia Yiangou, Nasim Mavaddat, Joe Dennis, Maria Zanti, Qin Wang, Manjeet K. Bolla, Mustapha Abubakar, Thomas U. Ahearn, Irene Louise Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Adinda Baten, , Paolo Radice

This study examines differences in polygenic risk score distributions across European populations and shows how country-specific calibration can improve breast cancer risk prediction.

medRxiv · Feb 12, 2024 · PreprintGenetic & Genomic Medicine

Reparameterization of PAM50 expression identifies novel breast tumor dimensions and leads to discovery of a breast cancer susceptibility locus at 12q15

Michael J. Madsen, Stacey Knight, Carol Sweeney, Rachel E. Factor, Mohamed E. Salama, Inge J. Stijleman, Venkatesh Rajamanickam, Bryan E. Welm, Sasi Arunachalam, Brandt Jones, Rakesh Rachamadugu, Kerry G. Rowe, Melissa H. Cessna, Alun Thomas, Lawrence H. Kushi, , Nicola J. Camp

The paper reparameterizes PAM50 gene expression into tumor dimensions and identifies a breast cancer susceptibility locus at 12q15 through genetic analysis of high-risk pedigrees.

Cancer Epidemiology Biomarkers & Prevention · Apr 12, 2018Peer-reviewedGenetics