Sasi Arunachalam

Somatic mitochondrial DNA mutations are a source of heterogeneity among primary leukemic cells

The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.

XenoCP: Cloud-based BAM cleansing tool for RNA and DNA from Xenograft

XenoCP is a cloud-based tool that removes mouse reads from xenograft BAM files to improve RNA-seq and WGS analysis accuracy.

Reparameterization of PAM50 expression identifies novel breast tumor dimensions and leads to discovery of a breast cancer susceptibility locus at 12q15

The paper reparameterizes PAM50 gene expression into tumor dimensions and identifies a breast cancer susceptibility locus at 12q15 through genetic analysis of high-risk pedigrees.