Venkatesh Rajamanickam

The paper identifies BAP1 as a tumor suppressor in soft tissue sarcoma using an in vivo CRISPR screen and shows that PLK1 inhibition can suppress tumor growth in BAP1-deficient models.

The paper reparameterizes PAM50 gene expression into tumor dimensions and identifies a breast cancer susceptibility locus at 12q15 through genetic analysis of high-risk pedigrees.

This paper introduces a new pedigree analysis method to identify risk variants for complex diseases, applying it to Multiple Myeloma and finding two genes associated with DNA repair and chromatin remodeling.

The paper uses a new pedigree analysis method to identify shared genomic segments in high-risk ASD families, finding one genome-wide significant segment and several suggestive regions.