GenomicsNature CancerPeer-reviewed
Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Yizhou Zhu, Hayan Lee, Shannon M. White…·Michael P. Snyder
This study shows that early colorectal cancer loses promoter-enhancer connectivity, leading to gene expression changes and a two-phase model of transcriptional regulation.