Yizhou Zhu

The paper introduces BIRT, a method for RNA sequencing that integrates barcoding and 3'-end capture during reverse transcription, improving accuracy and efficiency for low-input samples.

The paper identifies functional non-coding variants affecting Alzheimer's disease risk using MPRA and validates their effects through CRISPR/Cas9.

The paper identifies rare SIRT6 variants in centenarians that increase protein levels and delay cellular senescence, offering insights for geroprotective therapies.

This study shows that early colorectal cancer loses promoter-enhancer connectivity, leading to gene expression changes and a two-phase model of transcriptional regulation.

This paper introduces two 3C-derived methods, Tri-4C and Tri-HiC, for ultrafine mapping of chromatin interactions at 100 basepair resolution, revealing regulatory genome architecture and enhancer-promoter loops.

The paper identifies a functional variant in the 9p21.3 locus associated with glaucoma risk and shows it increases p16INK4a expression by disrupting YY1 binding.

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.

The paper uses ultra high-throughput methylation sequencing to study DNA methylation changes during colorectal cancer progression from normal tissue to adenocarcinoma.